Author: Dr. Steven Krause, MD Reviewed: 20 Aug 2019 A choice of the drug for the acne therapy depends on a severity level and causes of the disease. The essential role belongs to the derived agents of vitamin A among the drugs for the acne treatment. This group of medications acts on a cause of acne and neutralizes the clinical manifestations of this disease. One of the most popular products for the acne treatment is Accutane. What is Accutane (Roaccutane)? Accutane is a pharmaceutical product from retinoid group. It contains Isotretinoin ingredient. This ingredient has been for sale under the trade name Roaccutane on the market. The drug received the second name Accutane after the improvement of the molecular formula and an increased efficacy. The systemic monotherapy with Isotretinoin is the most effective method to treat the severest types of the acne: Acne conglobate; Nodulocystic acne; Acne with a risk of citarization; Rosacea. This ingredient also shows a high efficacy during the treatment of seborrhea and perioral dermatitis. According to the results of the clinical studies, the efficiency of isotretinoin is 96,4% in the treatment of the average and severe types of acne. Moreover, the disease has returned to patients within 5 years in less than 8% of the cases. The recurrent disease has been induced by the metabolic disorder. How does Accutane work? Accutane treats acne by means of the reduction of the sebum production. Its active ingredient Isotretinoin slows the cell fission sebaceous gland passages. In case of the severe proliferation of these cells, the sebaceous glands are clogged. Due to this, an evacuation of the sebaceous secretion is affected. Acne skin Isotretinoin not only cleans the passages to discharge sebum but also changes its structure. The secretion becomes softer and is easily excreted from the passages. Due to the recovery of the movement of the sebaceous secretion, the inflammatory process is reduced on the skin. It usually appears due to the active replication of bacteria in the clogged passages. Accutane regulates the activity of the sebaceous glands. In case of the intensive production of the sebum, the drug slows down this process. The regenerative processes are improved in dermis. It allows faster restoring the skin after the inflammatory processes, reducing a risk of cicatrices. How long does Accutane take to work? A therapeutic effect of Accutane may be felt within the first week of the treatment. The amount of the inflammatory parts on the skin and a number of the new rashes are usually reduced. However, every clinical case is individual. It depends on the severity of the disease and also on a cause of the acne development. The disease is often complicated by the infectious process in dermis. Due to this, the treatment may take long period. Therefore, the experienced dermatologists recommend having 2-3 week antibacterial therapy before taking Accutane. This will help to neutralize the pathogenic microflora and accelerate the development of the results during the use of Accutane. There are a lot of reviews about Accutane on the internet, and you may read them before the treatment. Having read the reviews of other users, you will find the same problem and get to know what effect to expect. There are also professional platforms where you may put your question about Accutane and get the answer of a professional doctor. Dr. Steven Krause (a professor dermatologist in Australia, 20 years of experience) helps people with severe types of acne to return a healthy and beautiful skin. According to his opinion, the first results of the treatment should be expected in 30 days. This is the period when Isotretinoin completely changes the functioning of the sebaceous glands and blocks the inflammatory reactions. But if you want to be healthy, take the pills for not less than 3 months. “Many people consider Accutane as a magical pill. But it is not true – said the professor. – You should understand that acne is a chronic disease which develops for years. It means that it is impossible to treat it within several weeks. If you expect fast results, you will never get rid of acne.” Accutane in Australia is top 1 product for acne but only because doctors know how to use it correctly. If you finish the treatment earlier, or are not going to follow the doctor’s recommendations, you will not receive the expected result. Accutane Safety Many people are afraid to take Accutane because it has a lot of side effects. However, the clinical studies have proved a safety of Accutane over the long run and dispelled a myth that it is a dangerous medication. As any drug, Accutane has some side effects. They aggravate during the overdose but they appear rare if the therapeutic doses are followed. However, you should be ready for the appearance of the Accutane side effects at any time: Headache; Muscle spasms; Nausea; Increased intracranial pressure; Skin peeling; Pain in muscles and joints; Dryness of the mucous membranes. Accutane pose a threat to pregnant women only. Isotretinoin even in a low dose provides a severest teratogenic action on fetus. It is able to break the formation of fetus or induce the birth defects. So, women at the reproductive age should have a medical examination and make sure that they are not pregnant. A doctor may prescribe you Accutane then. How to take Accutane and Roaccutane for the acne treatment? Accutane online is for sale in pills for the oral use: 10 mg, 20 mg, and 40 mg. Roaccutane is for sale in capsules for the oral use: 10 mg and 20 mg. The tablets/capsules are taken with food 2 times a day. A daily dose is divided into 2 parts in order to reduce a risk of the development of the side effects in the gastro-intestinal tract. The dose is individual. It depends on the disease severity and a patient’s health, contraindications, and body mass. The treatment is started from the minimal dose of 0,4-0,5 mg per 1 kg body mass a day. (if the body mass is 60 kg, the daily dose is 30 mg). The dose is gradually increased up to 2 mg/kg body mass in case of the affection of the back, neck, chest, or severe course of the disease. (if the body mass is 60 kg, the daily dose is 120 mg). Taking more than 2 mg per 1 kg body mass is pointless. This is the maximal safe dose that does not induce severe side effects. The treatment takes at least 12 weeks. The optimal period of the use of Accutane is 24 weeks. If the general clinical pattern has been improved by more than 80% within this period, the treatment is terminated. If the results do not satisfy a doctor or a patient in 24 weeks, the treatment is continued. The second course of the treatment is done after the break for 3 months. About Dr. Steven Krause, MD Dr. Steven Krause is a dermatologist in Reno, Nevada. He received his medical degree from Vanderbilt University School of Medicine and has been in practice for more than 20 years. As a board certified physician, Dr. Steven Krause, M.D., FAAD has the level of knowledge, experience and skills necessary to provide the highest quality, most comprehensive, state-of- the-art cosmetic, medical and surgical dermatologic care to patients who demand the very best.